Efficient decellularization for bovine pericardium with extracellular matrix preservation and good biocompatibility
نویسندگان
چکیده
منابع مشابه
Isolating Extracellular Matrix by Liver Decellularization
INTRODUCTION Liver Fibrosis is the 12th most leading cause of the death in the United States and 45% of all deaths in the developing world are caused by a fibrotic disease. [1] With the increase rate in fibrotic disease, there is an increased need for transplants which is exceeding the number of donors available. Fibrosis in the liver remains silent until it reaches the stage of liver failure, ...
متن کاملAnticalcification effects of decellularization, solvent, and detoxification treatment for genipin and glutaraldehyde fixation of bovine pericardium.
OBJECTIVE Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve substitutes. The objective of this study was to evaluate the anticalcification effect of decellularization and detoxification in glutaraldehyde (GA)/genipin- and solvent-fixed bovine pericardium using a rabbit intramuscular model which is effective for assessing calcification in bioprosthetic...
متن کاملDecellularization as an anticalcification method in stentless bovine pericardium valve prosthesis: a study in sheep.
OBJECTIVE The objective was to analyze the decellularization process with SDS in glutaraldehyde-preserved bovine pericardium as an anticalcification method in a circulatory sheep model. METHODS The valved tubs were implanted in pulmonary artery position in sheep by 180 days. The animals were divided in two groups of 8 animals: control group--glutaraldehyde-preserved bovine pericardium and the...
متن کاملEfficient decellularization for tissue engineering of the tendon-bone interface with preservation of biomechanics
Interfaces between tendon/ligament and bone ("entheses") are highly specialized tissues that allow for stress transfer between mechanically dissimilar materials. Entheses show very low regenerative capacity resulting in high incidences of failure after surgical repair. Tissue engineering is a promising approach to recover functionality of entheses. Here, we established a protocol to decellulari...
متن کاملHistologic Characteristics and Mechanical Properties of Bovine Pericardium Treated with Decellularization and α-Galactosidase: A Comparative Study
BACKGROUND Bioprostheses for cardiovascular surgery have limitations in their use following as calicification. α-galactosidase epitope is known as a stimulant of immune response and then shows a progressing calcification. The objective of this study was to evaluate histologic characteristics and mechanical properties of decellularization and treated with α-galactosidase. MATERIALS AND METHODS...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery
سال: 2018
ISSN: 1569-9293,1569-9285
DOI: 10.1093/icvts/ivx416